Brønsted acid catalyzed and NIS-promoted cyclization of diynones: selective synthesis of 4-pyrone, 4-pyridone, and 3-pyrrolone derivatives.

@article{Qiu2013BrnstedAC,
  title={Br\onsted acid catalyzed and NIS-promoted cyclization of diynones: selective synthesis of 4-pyrone, 4-pyridone, and 3-pyrrolone derivatives.},
  author={Yi-Feng Qiu and Fang Yang and Zi-Hang Qiu and Mei-jin Zhong and Li-Jing Wang and Yu-Ying Ye and Bo Geun Song and Yong-Min Liang},
  journal={The Journal of organic chemistry},
  year={2013},
  volume={78 23},
  pages={
          12018-28
        }
}
Brønsted acid catalyzed tandem cyclization was found to be highly effective for the preparation of a series of polysubstituted 4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone derivatives were also selectively synthesized by employing NIS and/or Brønsted acid. NIS as an electrophilic reagent could promote these reactions efficiently and rapidly under very mild reaction conditions. 

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