Brønsted-acid-catalyzed activation of nitroalkanes: a direct enantioselective aza-Henry reaction.

@article{Rueping2008BrnstedacidcatalyzedAO,
  title={Br\onsted-acid-catalyzed activation of nitroalkanes: a direct enantioselective aza-Henry reaction.},
  author={Magnus Rueping and Andrey P Antonchick},
  journal={Organic letters},
  year={2008},
  volume={10 9},
  pages={1731-4}
}
A direct asymmetric organocatalytic aza-Henry reaction has been developed in which a new bifunctional Brønsted-acid-catalyzed activation of nitroalkanes provides an efficient access to alpha,beta-diamino acids with high dia- and enantioselectivities under mild and base-free reaction conditions.