BpeAB-OprB, a Multidrug Efflux Pump in Burkholderia pseudomallei

  title={BpeAB-OprB, a Multidrug Efflux Pump in Burkholderia pseudomallei},
  author={Y. Y. Chan and T. Tan and Y. M. Ong and K. Chua},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={1128 - 1135}
  • Y. Y. Chan, T. Tan, +1 author K. Chua
  • Published 2004
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • ABSTRACT Burkholderia pseudomallei, the causative agent of melioidosis, is intrinsically resistant to a wide range of antimicrobial agents, including β-lactams, aminoglycosides, macrolides, and polymyxins. An operon, bpeR-bpeA-bpeB-oprB, which encodes a putative repressor, a membrane fusion protein, an inner membrane protein, and an outer membrane protein, respectively, of a multidrug efflux pump of the resistance-nodulation-division family was identified in B. pseudomallei. The divergently… CONTINUE READING
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