Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain.

@article{Verheggen2001BoxCS,
  title={Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain.},
  author={C{\'e}line Verheggen and John Mouaikel and Mark Thiry and Jean Marie Blanchard and David Tollervey and R{\'e}my Bordonn{\'e} and Denis L J Lafontaine and Edouard Bertrand},
  journal={The EMBO journal},
  year={2001},
  volume={20 19},
  pages={5480-90}
}
Nucleolar localization of box C/D small nucleolar (sno) RNAs requires the box C/D motif and, in vertebrates, involves transit through Cajal bodies (CB). We report that in yeast, overexpression of a box C/D reporter leads to a block in the localization pathway with snoRNA accumulation in a specific sub-nucleolar structure, the nucleolar body (NB). The human survival of motor neuron protein (SMN), a marker of gems/CB, specifically localizes to the NB when expressed in yeast, supporting… CONTINUE READING

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