Bowen's disease, Paget's disease, and malignant melanoma in situ.

@article{Rosen1986BowensDP,
  title={Bowen's disease, Paget's disease, and malignant melanoma in situ.},
  author={Les B. Rosen and K Amazon and Bradford L. Frank},
  journal={Southern medical journal},
  year={1986},
  volume={79 4},
  pages={410-3}
}
The histologic differential diagnosis of skin lesions characterized by large, atypical, clear cells in the epidermis includes Bowen's disease, Paget's disease (mammary and extramammary), malignant melanoma in situ (pagetoid precancerous melanosis), mycosis fungoides, Spitz nevus, and artifact. Our experience with these lesions indicates that these diseases can be differentiated immunohistologically by the standard peroxidase-antiperoxidase technique, using antibodies directed against keratin… CONTINUE READING