Bow to your partner for signaling


Seven years after Ballinger and Wells asked their challenging question “Will any dimer do?”1, the mechanism of receptor activation for many cytokine receptors still remains unclear. How is the information of extracellular ligand binding transmitted to the transmembrane and cytoplasmic regions? Are interactions between the transmembrane domains necessary to… (More)
DOI: 10.1038/nsmb0605-476


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