Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep.

@article{Androletti2006BovineSE,
  title={Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep.},
  author={Olivier Andr{\'e}oletti and Nathalie Morel and Caroline Lacroux and Virginie Rouillon and C{\'e}line Barc and Guillaume Tabouret and Pierre Sarradin and Patricia Berthon and Philippe Bernardet and Jacinthe Mathey and S{\'e}verine Lugan and Pierrette Costes and Fabien Corbi{\`e}re and Juan-Carlos Espinosa and Juan Maria Torres and J acques Grassi and François Schelcher and Fr{\'e}d{\'e}ric Lantier},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 4},
  pages={1043-6}
}
Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent… CONTINUE READING