Bovine sperm capacitation: assessment of phosphodiesterase activity and intracellular alkalinization on capacitation-associated protein tyrosine phosphorylation.

@article{GalantinoHomer2004BovineSC,
  title={Bovine sperm capacitation: assessment of phosphodiesterase activity and intracellular alkalinization on capacitation-associated protein tyrosine phosphorylation.},
  author={Hannah L Galantino-Homer and Harvey M Florman and Bayard T. Storey and Ina Dobrinski and Gregory S. Kopf},
  journal={Molecular reproduction and development},
  year={2004},
  volume={67 4},
  pages={487-500}
}
Mammalian sperm capacitation is the obligatory maturational process leading to the development of the fertilization-competent state. Heparin is known to be a unique species-specific inducer of bovine sperm capacitation in vitro and glucose a unique inhibitor of this induction. Heparin-induced capacitation of bovine sperm has been shown to correlate with protein kinase A (PKA)-dependent protein tyrosine phosphorylation driven by an increase in intracellular cAMP. This study examines the possible… CONTINUE READING

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