Bovine serum albumin adsorbed on eremomycin and grafted on silica as new mixed-binary chiral sorbent for improved enantioseparation of drugs.

@article{Fedorova2016BovineSA,
  title={Bovine serum albumin adsorbed on eremomycin and grafted on silica as new mixed-binary chiral sorbent for improved enantioseparation of drugs.},
  author={Irina A Fedorova and Elena N Shapovalova and Oleg A Shpigun and Sergey M Staroverov},
  journal={Journal of food and drug analysis},
  year={2016},
  volume={24 4},
  pages={
          848-854
        }
}
A new silica-based, mixed-binary chiral sorbent grafted with the macrocyclic antibiotic eremomycin and bovine serum albumin (BSA) was obtained. The sorbent-filled high-performance liquid chromatography column was capable of enantioseparation of racemic drugs, such as profens, in reversed-phase-chromatography mode. The mixed-binary eremomycin-BSA-sorbent showed better capability for profens enantioseparation as compared with a sorbent containing eremomycin only. BSA grafted onto the sorbent… CONTINUE READING