Bovine retinal explants cultured in collagen gels. A model system for the study of proliferative retinopathy.

@article{Forrester1990BovineRE,
  title={Bovine retinal explants cultured in collagen gels. A model system for the study of proliferative retinopathy.},
  author={John V. Forrester and Angela Chapman and Christine Kerr and Jim Roberts and W R Lee and J. M. Lackie},
  journal={Archives of ophthalmology},
  year={1990},
  volume={108 3},
  pages={415-20}
}
We have developed a model system for studying proliferative retinopathy in vitro using bovine retinal explants cultured in collagen gels. Cellular outgrowth from retinal explants occurred after 7 days as single cells from peripapillary explants or as cell sheets and tubular outgrowths from peripheral retinal explants. Single cell outgrowths were shown immunohistochemically to be endothelial cells or macrophages; sheetlike and tubular outgrowths also constituted cords of endothelial cells with… CONTINUE READING