Bovine papillomavirus type 1 E1 replication-defective mutants are altered in their transcriptional regulation.

@article{Lambert1988BovinePT,
  title={Bovine papillomavirus type 1 E1 replication-defective mutants are altered in their transcriptional regulation.},
  author={Paul F. Lambert and Peter M Howley},
  journal={Journal of virology},
  year={1988},
  volume={62 11},
  pages={4009-15}
}
Bovine papillomavirus type 1 (BPV-1) is capable of replicating as a stable, high-copy-number plasmid in transformed rodent cells. The BPV-1 E1 open reading frame (ORF) encodes multiple functions involved in viral DNA replication. Mutations which disrupt the translational integrity of the E1 ORF disable the viral genome from replicating as a stable plasmid and result in the integration of the viral genome into the host chromosome generally at a low copy number. Despite the low copy number of the… CONTINUE READING

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