Bovine papillomavirus E5 oncoprotein binds to the 16K component of vacuolar H+-ATPases


THE major transforming protein of bovine papillomavirus type 1, á£5 (refs 1–4), is mainly associated with endomembranes5, 6, specifically binding to a cellular protein of relative molecular mass 16,000 (16K) (ref. 7). At the same time as transformation, E5 causes the phosphorylation of tyrosine residues in epidermal and platelet-derived growth factor… (More)
DOI: 10.1038/352347a0


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