Bovine leukaemia virus-induced lymphocytosis in sheep is associated with reduction of spontaneous B cell apoptosis.

@article{SchwartzCornil1997BovineLV,
  title={Bovine leukaemia virus-induced lymphocytosis in sheep is associated with reduction of spontaneous B cell apoptosis.},
  author={Isabelle Schwartz-Cornil and Nathalie Chevallier and Catherine Belloc and Danielle Le Rhun and V Lain{\'e} and Madeleine Berthelemy and Alfonso Mateo and Dinah D. Levy},
  journal={The Journal of general virology},
  year={1997},
  volume={78 ( Pt 1)},
  pages={153-62}
}
Experimental inoculation of sheep with bovine leukaemia virus (BLV), a retrovirus homologous to the human T-lymphotropic virus type 1 (HTLV-1), induces a chronic expansion of the B lymphocyte population (persistent lymphocytosis) and the development of a B cell leukaemia/lymphosarcoma syndrome. To gain insight into the mechanisms of BLV-induced lymphocytosis, we tested B cell survival capacity and cycling activity in peripheral blood mononuclear cells (PBMCs) from lymphocytotic, asymptomatic… CONTINUE READING
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