Bovine herpesvirus type 1 (BHV-1) up-regulates telomerase activity in MDBK cells.

@article{Pagnini2006BovineHT,
  title={Bovine herpesvirus type 1 (BHV-1) up-regulates telomerase activity in MDBK cells.},
  author={Ugo Pagnini and Luisa De Martino and Serena Montagnaro and Assunta Diodato and Mariangela Longo and F. Pacelli and Giuseppe Pisanelli and Giuseppe Iovane},
  journal={Veterinary microbiology},
  year={2006},
  volume={113 3-4},
  pages={231-6}
}
The proliferative capacity of mammalian cells is regulated by telomerase, an enzyme uniquely specialised for telomeric DNA synthesis. The critical role of telomerase activation in tumor progression and maintenance has been well established in studies of cancer and of oncogenic transformation in cell culture. Experimental data suggest that telomerase activation has an important role in normal somatic cells, and that failure to activate sufficient telomerase also promotes disease. Evidence… CONTINUE READING