Bovine fetuin is an inhibitor of insulin receptor tyrosine kinase.

@article{Mathews1997BovineFI,
  title={Bovine fetuin is an inhibitor of insulin receptor tyrosine kinase.},
  author={Suresh T. Mathews and Pothur R. Srinivas and M. A. Leon and George Grunberger},
  journal={Life sciences},
  year={1997},
  volume={61 16},
  pages={
          1583-92
        }
}
Fetuin has been identified earlier as the bovine homolog of the human plasma protein, alpha2-Heremans Schmid glycoprotein (alpha2-HSG). Although bovine fetuin shares over 70% amino acid sequence similarity with alpha2-HSG and rat fetuin, no common function(s) have been identified. We report that immunoaffinity purified bovine fetuin acts as an inhibitor of insulin receptor tyrosine kinase activity (IR-TKA) with half-maximal inhibition at 1.5 microM. In vitro, bovine fetuin (1.5 microM) blocked… CONTINUE READING
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