Bovine binder-of-sperm protein BSP1 promotes protrusion and nanotube formation from liposomes.

@article{Lafleur2010BovineBP,
  title={Bovine binder-of-sperm protein BSP1 promotes protrusion and nanotube formation from liposomes.},
  author={Michel Lafleur and Lesley Courtemanche and G{\"o}ran Karlsson and Katarina Edwards and J. Schwartz and P. V. Manjunath},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={399 3},
  pages={406-11}
}
Binder-of-sperm (BSP) proteins interact with sperm membranes and are proposed to extract selectively phosphatidylcholine and cholesterol from these. This change in lipid composition is a key step in sperm capacitation. The present work demonstrates that the interactions between the protein BSP1 and model membranes composed with phosphatidylcholine lead to drastic changes in the morphology of the lipidic self-assemblies. Using cryo-electron microscopy and fluorescence microscopy, we show that… CONTINUE READING