Bovine adrenal medullary cells contain functional atrial natriuretic peptide receptors.

@article{Heisler1988BovineAM,
  title={Bovine adrenal medullary cells contain functional atrial natriuretic peptide receptors.},
  author={Seymour Heisler and E Morrier},
  journal={Biochemical and biophysical research communications},
  year={1988},
  volume={150 2},
  pages={
          781-7
        }
}
The recent report that bovine adrenal chromaffin cells synthesized and secreted atrial natriuretic peptide, ANP, suggested that the peptide may have binding sites in the gland itself. Studies in bovine adrenal medulla membranes did reveal a single class of high affinity [125I]-ANP binding sites with a KD of 94 pM and a density of 1.7 pmol/mg protein. Binding was very rapid (association half-time: 2.5 min), and specific in that only unlabelled ANP displaced bound [125I]-ANP. Application of ANP… CONTINUE READING

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