Bovine adrenal cortex transformations of mitotane [1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane; o,p'-DDD] and its p,p'- and m,p'-isomers.

@article{Cai1995BovineAC,
  title={Bovine adrenal cortex transformations of mitotane [1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane; o,p'-DDD] and its p,p'- and m,p'-isomers.},
  author={W. Cai and R. Benitez and R. Counsell and T. Djanegara and D. Schteingart and J. Sinsheimer and L. Wotring},
  journal={Biochemical pharmacology},
  year={1995},
  volume={49 10},
  pages={
          1483-9
        }
}
The adrenalytic activity of mitotane (o,p'-DDD) has made it useful in the treatment of adrenocortical carcinoma and Cushing's syndrome. In support of a study to develop mitotane analogs as more effective therapeutic agents and as a basis for understanding the toxicity of related compounds in the adrenals, the biotransformations of o,p'-DDD in adrenocortical homogenate preparations have been studied and compared with those of its m,p'- and p,p'-isomers. Aliphatic oxidation to the corresponding… Expand
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References

SHOWING 1-10 OF 27 REFERENCES
Metabolism of 1-(0-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p'-DDD) in rats.
  • V. Reif, J. Sinsheimer
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
  • 1975
Use of GC/MS/SIM for rapid determination of plasma levels of o,p'-DDD, o,p'-DDE and o,p'-DDA.
...
1
2
3
...