Bovine Pineal Tripeptide Threonylseryllysine Retards Puberty in Female Rats

@article{Benson1989BovinePT,
  title={Bovine Pineal Tripeptide Threonylseryllysine Retards Puberty in Female Rats},
  author={Bryant Benson},
  journal={Journal of Pineal Research},
  year={1989},
  volume={6}
}
  • B. Benson
  • Published 1989
  • Biology, Medicine
  • Journal of Pineal Research
When injected into rodents, the bovine pineal tripeptide threonylseryllysine (TSL) elicits diverse antireproductive effects in a number of animal models. Extensive studies of its effects on pubertal development have not been carried out, however. In the present study, 1.0 μg of T‐S‐L was administered daily to female Charles River CD rats throughout the peripubertal period, and effects on vaginal opening time, ovarian histology, and serum luteinizing hormone (LH) levels were observed. Since TSL… Expand
Melatonin administration during pregnancy retards sexual maturation of female offspring in the rat
TLDR
An inhibitory influence of melatonin during fetal life on the development of the neuroendocrine reproductive axis of the rat is shown, seeming to conform with the fact that exogenous melatonin crosses the placental barrier. Expand
Pineal proteins upregulate specific antioxidant defense systems in the brain
TLDR
It is suggested that buffalo (Bubalus bubalis) pineal proteins upregulates specific antioxidant defense systems and can be useful in control of various oxidative stress-induced neuronal diseases. Expand
Buffalo (Bubalus bubalis) epiphyseal proteins give protection from arsenic and fluoride‐induced adverse changes in acetylcholinesterase activity in rats
TLDR
Findings indicate the protective role of buffalo (Bubalus bubalis) epiphyseal proteins on F‐ and As‐induced adverse changes in AChE activity as a candidate biomarker for neurotoxicity in female rats. Expand
Small molecule complementarity as a source of novel pharmaceutical agents and combination therapies.
TLDR
It is argued that screening for molecular complementarity of small molecules turns ligands such as neurotransmitters and their metabolites, hormones, and drugs themselves, into direct targets of drug development that can augment screening new compounds for activity against receptors and second messenger systems. Expand

References

SHOWING 1-10 OF 14 REFERENCES
Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone.
TLDR
The results indicate that the pineal tripeptide may inhibit or modify FSH secretion in the mouse and rat. Expand
Bovine pineal antireproductive tripeptide binds to luteinizing hormone-releasing hormone: A model for peptide modulation by sequence specific peptide interactions?
We report results of chromatographic, pH titration and nuclear magnetic resonance (NMR) spectroscopy studies demonstrating that the bovine pineal antireproductive tripeptide, Thr-Ser-Lys (BPART),Expand
The onset of puberty in the female rat: changes in plasma prolactin, gonadotropins, luteinizing hormone-releasing hormone (LHRH), and hypothalamic LHRH content.
TLDR
It is suggested that the onset of puberty in the female rat is brought about by a gradual increase in estrogen secretion which, acting at the CNS-pituitary level, triggers a preovulatory proestrus-like surge of gonadotropins and prolactin. Expand
Endocrine Effects of Pineal Gland and of Melatonin
  • M. Motta, F. Fraschini, L. Martini
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1967
TLDR
In prepuberal female rats melatonin retards puberty and decreases pituitary weight as well as the weights of the ovaries and the uteri, confirming that melatonin reduces LH secretion. Expand
AN INHIBITORY EFFECT OF MELATONIN ON THE ESTROUS PHASE OF THE ESTROUS CYCLE OF THE RODENT.
Microgram doses of melatonin decrease the incidence of vaginal smears that demonstrate estrous phases in Sprague- Dawley rats and C3H/HeN mice. This property is not shared by the precursors ofExpand
Daily administration of melatonin delays rat vaginal opening and disrupts the first estrous cycles: evidence that these effects are synchronized by the onset of light.
TLDR
The results confirm that chronic melatonin administration delays sexual maturation of female rat, probably by retarding m maturity of hypothalamic GnRH-producing cells, and raises the possibility that the abnormal presence of endogenous melatonin during this period of the day could induce abnormal sexual development. Expand
Isolation, purification and amino acid sequence of a tripeptide from bovine pineal tissue displaying antigonadotropic properties.
TLDR
Inhibition of compensatory ovarian hypertrophy in adult mice was used as an index of activity to guide the purification of a bovine pineal extract in order to isolate peptides displaying antigonadotropic properties from bovines pineal tissue. Expand
Amino acid pairing.
TLDR
A set of amino acid pairings are presented which may allow protein-to-protein information transfers and its implications for the Central Dogma and theories of the origin of life are discussed. Expand
Influence of Thr - Ser - Lys ( TSL ) , a recently isolated pineal peptide , on ovarian and uterine weights and estrous cycles in mice , hamsters and rats . I n Pineal Function
  • 1981
...
1
2
...