Bovine IgG repertoire is dominated by a single diversified VH gene family.

@article{Sinclair1997BovineIR,
  title={Bovine IgG repertoire is dominated by a single diversified VH gene family.},
  author={M C Sinclair and Julie Gilchrist and Robert Aitken},
  journal={Journal of immunology},
  year={1997},
  volume={159 8},
  pages={3883-9}
}
Using methods based upon the PCR, we have analyzed sequences that encode the V domain of bovine Ig heavy chain. Pairwise comparison indicates that the heavy chain repertoire in cattle is dominated by a single VH gene family that is homologous to human VHII. The third complementarity-determining region (CDR3) is particularly variable and 60% of the sequences encode a CDR3 in excess of 21 amino acids. Southern blots, single-stranded conformation polymorphism analysis, and sequencing of segments… CONTINUE READING

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