Boundary formation and maintenance in tissue development

  title={Boundary formation and maintenance in tissue development},
  author={Christian Dahmann and Andrew C. Oates and Michael Brand},
  journal={Nature Reviews Genetics},
The formation and maintenance of boundaries between neighbouring groups of embryonic cells is vital for development because groups of cells with distinct functions must often be kept physically separated. Furthermore, because cells at the boundary often take on important signalling functions by acting as organizing centres, boundary shape and integrity can also control the outcome of many downstream patterning events. Recent experimental findings and theoretical descriptions have shed new light… 
Regulation of cell adhesion and cell sorting at embryonic boundaries.
  • F. Fagotto
  • Biology
    Current topics in developmental biology
  • 2015
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Key to the separation of compartments is a local increase of actomyosin‐dependent mechanical tension at cell junctions along the boundary, which acts as a barrier to cell mixing during cell division and influences cell rearrangements during cell intercalations along the compartment boundary in a way that the straight shape of the boundary is maintained.
Physical Mechanisms Shaping the Drosophila Dorsoventral Compartment Boundary
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Hydra, a representative of the basally branching metazoan Cnidaria, is an interesting prebilaterian model system to study the emergence of boundary-forming mechanisms during evolution.
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Studies of vertebrate hindbrain development have given important insights into mechanisms that underlie the formation and maintenance of sharp borders, including the regulation of cell adhesion and contact inhibition of cell migration.
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The results of recent studies have clarified where compartment boundaries exist, shed light on molecular mechanisms that underlie their formation and have revealed an important function of these boundaries: the positioning and stabilization of local signalling centres.
Cellular morphology and extracellular space at rhombomere boundaries in the chick embryo hindbrain
  • I. Heyman, A. Kent, A. Lumsden
  • Biology
    Developmental dynamics : an official publication of the American Association of Anatomists
  • 1993
It is found that the boudary regions of the chick embryo hindbrain contain enlarged extracellular spaces and that these form conduits for axons subsequently extending in the circumferential plane of the hindbrain.
An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos
It is shown that cells can transiently invade neighbouring compartments, especially when they divide, but are then pushed back into their compartment of origin, and proposed that local regulation of actomyosin contractibility, rather than differential adhesion, is the primary mechanism sorting cells at compartmental boundaries.
Dynamic 3D Cell Rearrangements Guided by a Fibronectin Matrix Underlie Somitogenesis
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It is suggested that the boundary-forming signals emanating from the posterior border cells are mediated by Notch, the action of which is confined to the border region by Lunatic fringe within the area where mRNAs of Notch and its ligand are broadly expressed in the presomitic mesoderm.
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It is shown that anisotropy of cortical tension at apical cell junctions is sufficient to drive tissue elongation in Drosophila melanogaster embryos, and the contribution of subcellular tensile activity polarizing junction remodelling and the permissive role of vertex fluctuations during tissues elongation is delineated.