Boundary cap cells are highly competitive for CNS remyelination: fast migration and efficient differentiation in PNS and CNS myelin-forming cells.

@article{Zujovic2010BoundaryCC,
  title={Boundary cap cells are highly competitive for CNS remyelination: fast migration and efficient differentiation in PNS and CNS myelin-forming cells.},
  author={Violetta Zujovic and Julie Thibaud and Corinne Bachelin and Marie Vidal and Fanny Coulpier and Patrick Charnay and Piotr Topilko and Anne Baron-Van Evercooren},
  journal={Stem cells},
  year={2010},
  volume={28 3},
  pages={470-9}
}
During development, boundary cap cells (BC) and neural crest cell (NCC) derivatives generate Schwann cells (SC) of the spinal roots and a subpopulation of neurons and satellite cells in the dorsal root ganglia. Despite their stem-like properties, their therapeutic potential in the diseased central nervous system (CNS) was never explored. The aim of this work was to explore BC therapeutic potential for CNS remyelination. We derived BC from Krox20(Cre) x R26R(Yfp) embryos at E12.5, when Krox20 is… CONTINUE READING