Bound lectins that mimic insulin produce persistent insulin-like activities.


Short preincubation of rat adipocytes with wheat germ agglutinin, followed by removal of unbound lectin, resulted in persistent activation of lipogenesis, which lasted at least 3 h. The bound lectin also inhibited lipolysis initiated by isoproterenol 1 or 2 h after the removal of the free lectin. This property was also shared by other insulinomimetic… (More)


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