Botulism Diagnostics: From Clinical Symptoms to in vitro Assays

  title={Botulism Diagnostics: From Clinical Symptoms to in vitro Assays},
  author={S. Cai and B. Singh and S. Sharma},
  journal={Critical Reviews in Microbiology},
  pages={109 - 125}
  • S. Cai, B. Singh, S. Sharma
  • Published 2007
  • Biology, Medicine
  • Critical Reviews in Microbiology
  • Botulinum neurotoxin (BoNT), which cause the deadly neuroparalytic disease, botulism, is the most toxic substance known to man. BoNT can be used as potential bioterrorism agents, and therefore, pose great threat to national security and public health. Rapid and sensitive detection of BoNTs using molecular and biochemical techniques is an essential component in the diagnosis of botulism, and is yet to be achieved. The most sensitive and widely accepted assay method for BoNTs is mouse bioassay… CONTINUE READING
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