Botulism Diagnostics: From Clinical Symptoms to in vitro Assays

@article{Cai2007BotulismDF,
  title={Botulism Diagnostics: From Clinical Symptoms to in vitro Assays},
  author={S. Cai and B. Singh and S. Sharma},
  journal={Critical Reviews in Microbiology},
  year={2007},
  volume={33},
  pages={109 - 125}
}
  • S. Cai, B. Singh, S. Sharma
  • Published 2007
  • Biology, Medicine
  • Critical Reviews in Microbiology
  • Botulinum neurotoxin (BoNT), which cause the deadly neuroparalytic disease, botulism, is the most toxic substance known to man. BoNT can be used as potential bioterrorism agents, and therefore, pose great threat to national security and public health. Rapid and sensitive detection of BoNTs using molecular and biochemical techniques is an essential component in the diagnosis of botulism, and is yet to be achieved. The most sensitive and widely accepted assay method for BoNTs is mouse bioassay… CONTINUE READING
    106 Citations

    Topics from this paper

    Rapid Detection of Botulinum Neurotoxins—A Review
    • 12
    • PDF
    Rapid Microfluidic Assay for the Detection of Botulinum Neurotoxin in Animal Sera
    • 12
    • Highly Influenced
    • PDF
    In Vitro Detection and Quantification of Botulinum Neurotoxin Type E Activity in Avian Blood
    • 25
    • PDF
    Sensing the Deadliest Toxin: Technologies for Botulinum Neurotoxin Detection
    • 36
    • Highly Influenced
    • PDF
    Detection of six serotypes of botulinum neurotoxin using fluorogenic reporters.
    • 43

    References

    SHOWING 1-10 OF 147 REFERENCES
    Evaluation of Lateral-Flow Clostridium botulinum Neurotoxin Detection Kits for Food Analysis
    • 94
    • PDF
    Development of in vitro assays for the detection of botulinum toxins in foods.
    • 51
    • Highly Influential
    • PDF
    Methods for detection of Clostridium botulinum toxin in foods.
    • 69
    Detection of botulinum neurotoxin A in a spiked milk sample with subtype identification through toxin proteomics.
    • 66
    • Highly Influential
    The use of Endopep-MS for the detection of botulinum toxins A, B, E, and F in serum and stool samples.
    • 115
    High-throughput assays for botulinum neurotoxin proteolytic activity: serotypes A, B, D, and F.
    • 91
    Detection of botulinal neurotoxins A, B, E, and F by amplified enzyme-linked immunosorbent assay: collaborative study.
    • 76
    • Highly Influential
    • PDF
    Human botulism immune globulin for the treatment of infant botulism.
    • 171
    • PDF
    Comparison of electrochemiluminescence assay and ELISA for the detection of Clostridium botulinum type B neurotoxin.
    • 51
    • Highly Influential