Botulinum toxin type B in blepharospasm and hemifacial spasm

  title={Botulinum toxin type B in blepharospasm and hemifacial spasm},
  author={Gabor C Petzold and Jos{\'e} Manuel Valdueza},
Botulinum neurotoxins (BTXs) inhibit the presynaptic release of acetylcoline causing a chemical denervation that results in sustained muscle weakness and have been used in the past 20 years to induce selective blocking of hyperactive striatal (and smooth) muscles. All the different seven serotypes of BTXs have in common the mechanism of action (block of the neuroexocytosis machinery inside the end plate, responsible for the release of acetylcholine into the neuromuscular junction), acting on… CONTINUE READING
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