Botulinum toxin type A normalizes alterations in urothelial ATP and NO release induced by chronic spinal cord injury.

  title={Botulinum toxin type A normalizes alterations in urothelial ATP and NO release induced by chronic spinal cord injury.},
  author={Christopher Patrick Smith and David A Gangitano and Alvaro Munoz and Nilson A. Salas and Timothy B. Boone and Kei Roger Aoki and Joseph Rabinson Francis and George T. Somogyi},
  journal={Neurochemistry international},
  volume={52 6},
The purpose of this paper was to simultaneously examine changes in urothelial ATP and NO release in normal and spinal cord injured animals as well as in spinal cord injured animals treated with botulinum toxin type A (BoNT-A). Furthermore we correlated changes in transmitter release with functional changes in bladder contraction frequency, and determined the effects of BoNT-A on bladder efferent nerve function. Normal and spinal cord injured rat bladders were injected on day 0 with either… CONTINUE READING


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