Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation.

@article{Lucioni2008BotulinumTT,
  title={Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation.},
  author={Alvaro Lucioni and Gregory T. Bales and Tamara L Lotan and Daniel S McGehee and Sean Peter Cook and David E. Rapp},
  journal={BJU international},
  year={2008},
  volume={101 3},
  pages={366-70}
}
OBJECTIVE To determine the effect of botulinum toxin type A (BTX-A) on the release of the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) from isolated bladder preparations after acute injury with HCl and the induction of cyclophosphamide (CYP)-induced cystitis, as neurogenic inflammation has been increasingly identified in urological disorders such as interstitial cystitis. MATERIALS AND METHODS Adult rats had either an intraperitoneal injection with CYP or saline… CONTINUE READING

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