Botulinum toxin type A induces direct analgesic effects in chronic neuropathic pain.

  title={Botulinum toxin type A induces direct analgesic effects in chronic neuropathic pain.},
  author={Dani{\`e}le Ranoux and Nadine Attal and Françoise Morain and Didier Bouhassira},
  journal={Annals of neurology},
  volume={64 3},
OBJECTIVE Botulinum toxin type A (BTX-A) has been reported to have analgesic effects independent of its action on muscle tone, possibly by acting on neurogenic inflammation. Such a mechanism may be involved in peripheral neuropathic pain. METHODS A possible direct analgesic effect of BTX-A pain processing was investigated in 29 patients with focal painful neuropathies and mechanical allodynia using a randomized, double-blind, placebo-controlled design. Patients received a one-time intradermal… CONTINUE READING


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