Botulinum toxin type A (BOTOX) for treatment of migraine headaches: An open-label study

@article{Binder2000BotulinumTT,
  title={Botulinum toxin type A (BOTOX) for treatment of migraine headaches: An open-label study},
  author={William J. Binder and Mitchell F Brin and Andrew Blitzer and Larry D. Schoenrock and Janice M. Pogoda},
  journal={Otolaryngology–Head and Neck Surgery},
  year={2000},
  volume={123},
  pages={669 - 676}
}
ABSTRACT OBJECTIVE: The object of this clinical experience was to evaluate the correlation between pericranial botulinum toxin type A (BOTOX, Allergan Corp, Irvine, CA) administration and alleviation of migraine headache symptoms. STUDY DESIGN AND SETTING: A nonrandomized, open-label study was performed at 4 different test sites. The subjects consisted of 106 patients, predominantly female, who either (1) initially sought BOTOX treatment for hyperfunctional facial lines or other dystonias with… 
Botulinum toxin: could it be an effective treatment for chronic tension-type headache?
TLDR
BTX-A was an effective and well-tolerated prophylactic treatment in Egyptian patients with CCTH and showed significant improvement after 1 month of BTx-A injection regarding headache days/month, severity measured by VAS and HDI in headache severity.
Botulinum Toxin A Treatment in Chronic Daily Headache
TLDR
Age and duration of migraine were found to be predictive of treatment response while attack frequency, analgesic overuse, Botox dose and muscle tenderness were not, and statistically significant differences between Botoxand placebo-treated groups were observed to favor Botox for the change from baseline headache frequency and severity at multiple time points.
Botulinum Toxin Type A Therapy in Chronic Headache Patients
TLDR
Significant decreases in the VAS for pain were found in both the chronic migraine and non-migraine CH groups, from 2, 4 and 12 weeks and from 4 and 10 weeks, respectively, after BoNT-A administration.
Botulinum toxin type A for migraine prophylaxis in the Japanese population: an open-label prospective trial.
TLDR
BoNT-A injection was an effective and safe treatment for migraine prophylaxis among the Japanese population and a randomized placebo control trial is necessary to confirm its efficacy.
Role of Botulinum Toxin Type A in the Prophylactic Treatment of Migraine Headaches
TLDR
The results of 3 double-blind, placebo-controlled trials, 2 retrospective chart reviews, and an open-label study indicate that botulinum toxin type A may be a safe and efficacious prophylactic treatment for migraine headaches.
Botulinum toxin and the management of chronic headaches
  • S. Evers
  • Medicine
    Current opinion in otolaryngology & head and neck surgery
  • 2004
TLDR
The studies available from reference systems and published congress contributions on the prophylactic treatment of idiopathic and cervicogenic headache with botulinum toxin were analyzed with respect to study design, headache diagnosis, and the significance of results.
Botulinum toxin in migraine prophylaxis
TLDR
A number of other randomized, placebo-controlled, clinical trials are being conducted to evaluate the efficacy, optimal dosing, and side-effect profile of botulinum toxin type A in the prophylaxis of migraine and other headache entities.
Use of Botulinum Toxins for Chronic Headaches: A Focused Review
TLDR
Current data suggest that botulinum toxin is safe and does not produce systemic effects associated with other types of headache treatments, and it may also provide peripheral and central neurogenic effects and reduce inflammation.
Status on the use of botulinum toxin for headache disorders
  • S. Evers
  • Medicine
    Current opinion in neurology
  • 2006
TLDR
The majority of double-blind and placebo-controlled studies do not confirm the assumption that botulinum toxin A is efficacious in the treatment of idiopathic headache disorders, but it is possible that subgroups of patients with chronic daily headache benefit from a long-term treatment with this substance.
Botulinum toxin type A in prophylactic treatment of migraine headaches: a preliminary study
TLDR
Botulinum toxin type A injections were well tolerated and provided effective migraine prophylaxis in these patients, and one patient experienced mild, transient frontalis muscle weakness lasting approximately 30 days.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 29 REFERENCES
Botulinum A Neurotoxin for Axillary Hyperhidrosis No Sweat Botox
  • R. Glogau
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 1998
TLDR
The utility of using Botox in the treatment of axillary hyperhidrosis was demonstrated with relatively complete anhidrosis of the axillary skin in periods ranging from 4 to 7 months.
The management of hyperfunctional facial lines with botulinum toxin. A collaborative study of 210 injection sites in 162 patients.
TLDR
Evaluation by age and site suggested a trend of increased toxin dose with increased age, and botulinum toxin is a safe and important adjunctive technique for the management of patients with symptomatic hyperfunctional facial lines.
Rhinorrhea is Decreased in Dogs after Nasal Application of Botulinum Toxin
TLDR
It is concluded that topically applied botulinum toxin reduced neurally evoked rhinorrhea by an average of 41%.
Clinical and pathophysiological observations in migraine and tension-type headache explained by integration of vascular, supraspinal and myofascial inputs
TLDR
The model gives a rational explanation of empirically developed, internationally accepted, multimodal treatment strategies for migraine and tension‐type headache and explains much of the complexity of the clinical picture of these disorders as well as their tendency to overlap and to change into one another.
Treatment of Hyperfunctional Lines of the Face with Botulinum Toxin A
  • W. Binder, A. Blitzer, M. Brin
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 1998
TLDR
The following article summarizes the experience in establishing a safe and reliable method of administration of botulinum toxin A for treating hyperfunctional lines of the face.
Psychophysiology of recurrent headache: Methodological issues and new empirical findings
Traditional accounts of headache attribute migraine to an unstable vasomotor system and tension to prolonged contraction of skeletal muscles. Investigations of the psychophysiology of headache
Pathophysiology of migraine and tension-type headache.
  • A. Zagami
  • Medicine
    Current opinion in neurology
  • 1994
TLDR
Anatomical studies delineate some of the sites involved in the central processing of craniovascular nociception and 5-Hydroxytryptamine receptors, particularly 5-HT1, are implicated in the pathogenesis of migraine.
Status epilepticus and antiepileptic medication levels
TLDR
Citing AED irregularity as the major cause of SE in patients with epilepsy oversimplifies a complex, poorly understood situation.
Correlation between essential tremor and migraine headache.
TLDR
There is an association between essential tremor and migraine, and the prevalence of ET in migraine controls was greater than controls without migraine.
Migraine classification and diagnosis. International Headache Society criteria.
TLDR
The IHS criteria for migraine provide one method for targeting a group of headache patients in need of care, providing uniform terminology for clinical practice, multinational clinical trials, and biologic and epidemiologic research.
...
1
2
3
...