Botulinum toxin for treating spasmodic dysphonia (laryngeal dystonia): a systematic Cochrane review

@article{Watts2006BotulinumTF,
  title={Botulinum toxin for treating spasmodic dysphonia (laryngeal dystonia): a systematic Cochrane review},
  author={Christopher R. Watts and Chad Nye and Renata Whurr},
  journal={Clinical Rehabilitation},
  year={2006},
  volume={20},
  pages={112 - 122}
}
Background: Spasmodic dysphonia is a neurological voice disorder characterized by involuntary adductor (towards midline) or abductor (away from midline) vocal fold spasms during phonation which result in phonatory breaks. Botulinum toxin is currently the gold standard of treatment. Objective: To determine the efficacy of botulinum toxin therapy for the treatment of spasmodic dysphonia. Design: Systematic Cochrane review. Search strategy: The search strategy for this review complied with… 
Botulinum Toxin Therapy: A Series of Clinical Studies on Patients with Spasmodic Dysphonia in Japan
TLDR
A placebo-controlled, randomized, double-blinded clinical trial of BT therapy was conducted; this was effective and safe, and BT treatment is now funded by the Japanese medical insurance scheme.
[Botulinum toxin efficacy in the treatment of patients with spasmodic dysphonia].
TLDR
The majority of patients with spasmodic dysphonia experienced both subjective improvement and the improvement in the terms of the quality of life, Voice Henolicap Index--(VHI) that was rated as rather significant one.
Retrospective review of dosing trends in botulinum toxin injections for the treatment of adductor spasmodic dysphonia in a long-term cohort
TLDR
The majority of patients in this study had decreasing BT injection dosages over time, with a smaller proportion having slowly increasing doses, thought to be likely relating to disease severity.
Unilateral versus bilateral thyroarytenoid Botulinum toxin injections in adductor spasmodic dysphonia: a prospective study
TLDR
Unilateral low dose Dysport injections are recommended in the treatment of adductor spasmodic dysphonia because they are associated with no significant difference in the patient's outcome in terms of duration of action, voice score (VS) and complication rate.
Tratamento médico e fonoaudiológico da disfonia espasmódica: uma revisão bibliográfica
TLDR
The treatments using lidocaine and homeopathy had positive results in relation to the voice quality of the patients and were suggested as an option for those who wouldn't like to undergo surgical treatment or have botulinum toxin injection.
Treatment of Focal Dystonia
TLDR
Patient education and directing the patients towards dystonia support groups and relevant websites that provide scientific information may be useful for long-term compliance and benefit.
Outcomes of Onabotulinum Toxin A Treatment for Adductor Spasmodic Dysphonia and Laryngeal Tremor
TLDR
Onabotulinum toxin A injections into the thyroarytenoids/lateral cricoarytenoid muscle complex are an effective treatment for ADSD, ADSD+LT, and LT without ADSD; however, the greatest effectiveness was observed among patients with ADSD.
Hemodynamic Changes Associated With Transcervical Laryngeal Injection of Botulinum Toxin.
Evidence for the effectiveness of botulinum toxin for spasmodic dysphonia from high-quality research designs
TLDR
Based on the quality of evidence scale used, botulinum toxin can be considered an effective treatment for adductor spasmodic dysphonia.
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TLDR
The evidence from randomized controlled trials does not allow firm conclusions to be drawn about the effectiveness of botulinum toxin for all types of spasmodic dysphonia, or for patients with different behavioral or clinical characteristics.
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TLDR
A newly developed method of treatment differs from reported methods by increasing the accuracy of botulinum toxin placement, reducing soft tissue trauma, and applying basic scientific information about the functional histology of intrinsic laryngeal musculature.
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TLDR
Botulinum toxin A injection of the laryngeal hyperfunctional muscles has been found over the past 12 years to be the treatment of choice to control the dystonic symptoms in most patients with spasmodic dysphonia.
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TLDR
Patients received benefit within 24 to 72 hours, with sustained improvement for 2 to 9 months with an average of 4 months, and BOTOX has become the treatment of choice for dystonic conditions of the larynx.
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TLDR
Most patients with adductor spasmodic dysphonia treated with percutaneous injections of botulinum toxin preferred the bilateral injection, in spite of more and longer-lasting side effects.
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TLDR
PCA muscle injections of Botox provided limited benefits to patients with ABSD, demonstrating the need for a more effective therapy for these patients.
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TLDR
Botulinum toxin A proved to be an effective and safe treatment of adductor spasmodic dysphonia and markedly reduced perturbation, decreased fundamental frequency range, and improved the spectrographic characteristics of the voice.
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TLDR
The results suggest that changes in the central pathophysiology are responsible for changes in speech symptoms following treatment in persons with adductor spasmodic dysphonia.
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