Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction

@article{Irani2008BotulinumTF,
  title={Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction},
  author={Katy Irani and Leonel Rodriguez and Daniel P. Doody and Allan M Goldstein},
  journal={Pediatric Surgery International},
  year={2008},
  volume={24},
  pages={779-783}
}
Internal anal sphincter (IAS) dysfunction is a cause of refractory constipation in children. The goal of this study was to determine whether intrasphincteric injection of botulinum toxin is effective in the treatment of constipation in pediatric patients with IAS dysfunction. A retrospective review was performed of 24 pediatric patients with intractable constipation. All patients had abnormal anorectal manometry, with either elevated IAS resting pressure (≥100 mm Hg) or an absent or diminished… CONTINUE READING

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Internal anal sphincter achalasia: relationship with colonic dysmotility and manometric response to botulinum toxin injection

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