Botulinum toxin for simple motor tics: a randomized, double-blind, controlled clinical trial.

@article{Marras2001BotulinumTF,
  title={Botulinum toxin for simple motor tics: a randomized, double-blind, controlled clinical trial.},
  author={Connie Marras and D. Andrews and Elspeth Sime and Anthony E Lang},
  journal={Neurology},
  year={2001},
  volume={56 5},
  pages={605-10}
}
OBJECTIVE To determine the effect of injections of botulinum toxin on simple motor tics. BACKGROUND Case series with unblinded assessments have reported improvement in tic frequency and associated urge with botulinum toxin. METHODS Patients with suitable simple motor tics were randomized to receive botulinum toxin and placebo in a double blind, crossover design. All outcomes compared week 2 to baseline measurements. The primary outcome measure was the number of treated tics per minute on a… CONTINUE READING

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