Botulinum toxin as a carrier for oral vaccines

  title={Botulinum toxin as a carrier for oral vaccines},
  author={Lance L. Simpson and Andrew B Maksymowych and Nadya Kiyatkin},
  journal={Cellular and Molecular Life Sciences CMLS},
Botulinum toxin is an unusually potent substance that acts on the nervous system to produce the clinical outcome of flaccid paralysis. To produce this effect, the toxin ordinarily proceeds through two separate but essential sequences of events. During the first, the toxin is ingested, it traverses a portion of the gastrointestinal system and then it is transcytosed from the lumen of the gut to the general circulation. During the second, circulating toxin binds to peripheral cholinergic nerve… CONTINUE READING