Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity

@inproceedings{Matsumura2015BotulinumTA,
  title={Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity},
  author={Takuhiro Matsumura and Yo Sugawara and Masahiro Yutani and Sho Amatsu and H. Yagita and Tomoko Kohda and Shin-ichi Fukuoka and Yutaka Nakamura and Shinji Fukuda and Koji Hase and Hiroshi Ohno and Yukako Fujinaga},
  booktitle={Nature communications},
  year={2015}
}
To cause food-borne botulism, botulinum neurotoxin (BoNT) in the gastrointestinal lumen must traverse the intestinal epithelial barrier. However, the mechanism by which BoNT crosses the intestinal epithelial barrier remains unclear. BoNTs are produced along with one or more non-toxic components, with which they form progenitor toxin complexes (PTCs). Here we show that serotype A1 L-PTC, which has high oral toxicity and makes the predominant contribution to causing illness, breaches the… CONTINUE READING
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