Botulinum toxin A blocks glutamate exocytosis from guinea-pig cerebral cortical synaptosomes.

@article{SnchezPrieto1987BotulinumTA,
  title={Botulinum toxin A blocks glutamate exocytosis from guinea-pig cerebral cortical synaptosomes.},
  author={Jos{\'e} S{\'a}nchez-Prieto and Talvinder S. Sihra and Diane Evans and Alun Ashton and J Oliver Dolly and Dr M. Gary Nicholls},
  journal={European journal of biochemistry},
  year={1987},
  volume={165 3},
  pages={675-81}
}
The exocytotic release of L-glutamate from guinea-pig cerebral cortical synaptosomes can be extensively inhibited by preincubation with botulinum neurotoxin type A at 37 degrees C for 1-2 h. The toxin has no effect on synaptosomal respiratory control, respiratory capacity, ATP synthesis, plasma-membrane 86Rb+ permeability or plasma-membrane potential, does not inhibit the entry of 45Ca2+ into the synaptosome upon depolarization and does not alter the ability of intrasynaptosomal mitochondria to… CONTINUE READING

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