Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor.

@article{Rummel2009BotulinumNC,
  title={Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor.},
  author={Andreas Rummel and Kirstin H{\"a}fner and Stefan Mahrhold and Natallia Darashchonak and Matthew V Holt and Reinhard Jahn and Silke Beermann and Tino Karnath and Hans Bigalke and Thomas Binz},
  journal={Journal of neurochemistry},
  year={2009},
  volume={110 6},
  pages={
          1942-54
        }
}
The high toxicity of clostridial neurotoxins primarily results from their specific binding and uptake into neurons. At motor neurons, the seven botulinum neurotoxin serotypes A-G (BoNT/A-G) inhibit acetylcholine release, leading to flaccid paralysis, while tetanus neurotoxin blocks neurotransmitter release in inhibitory neurons, resulting in spastic paralysis. Uptake of BoNT/A, B, E and G requires a dual interaction with gangliosides and the synaptic vesicle (SV) proteins synaptotagmin or SV2… CONTINUE READING

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Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin.

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