Botulinum neurotoxin type A counteracts neuropathic pain and facilitates functional recovery after peripheral nerve injury in animal models.

@article{Marinelli2010BotulinumNT,
  title={Botulinum neurotoxin type A counteracts neuropathic pain and facilitates functional recovery after peripheral nerve injury in animal models.},
  author={S. Marinelli and Siro Luvisetto and Stefano Cobianchi and Wioletta Makuch and Ilona Obara and Eleonora Mezzaroma and Maggie Caruso and Elisabetta Straface and Barbara Przewlocka and Flaminia Pavone},
  journal={Neuroscience},
  year={2010},
  volume={171 1},
  pages={316-28}
}
A growing interest was recently focused on the use of Botulinum neurotoxin serotype A (BoNT/A) for fighting pain. The aim of this study was to investigate the effects of BoNT/A on neuropathic pain. It was observed that BoNT/A is able to counteract neuropathic pain induced by chronic constriction injury (CCI) to the sciatic nerve both in mice and in rats. This effect is already present after a single intraplantar (i.pl.) or intrathecal (i.t.) neurotoxin administration that significantly reduces… CONTINUE READING

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