Botulinum Toxin Treatment of Movement Disorders

@article{Safarpour2018BotulinumTT,
  title={Botulinum Toxin Treatment of Movement Disorders},
  author={Yasaman Safarpour and Bahman Jabbari},
  journal={Current Treatment Options in Neurology},
  year={2018},
  volume={20},
  pages={1-17}
}
Botulinum neurotoxins (BoNTs) are now among the most widely used therapeutic agents in clinical medicine with indications applied to the fields of movement disorders, pain disorders, and autonomic dysfunction. In this literature review, the efficacy and utility of BoNTs in the field of movement disorders are assessed using the criteria of the Guideline Development Subcommittee of the American Academy of Neurology. The literature supports a level A efficacy (established) for BoNT therapy in… Expand
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TLDR
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TLDR
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Evidence for central antispastic effect of botulinum toxin type A
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  • Medicine
  • British journal of pharmacology
  • 2019
TLDR
Botulinum toxin type A injections into hyperactive muscles provide effective treatment for spasticity and dystonias, presumably due to its local effects on extrafusal and intrafusal motor fibres, but functional consequences of BoNT/A direct central action on abnormally increased muscle tone are presently unknown. Expand
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Evidence-based review and assessment of botulinum neurotoxin for the treatment of movement disorders.
TLDR
An expert panel reviewed evidence from the published literature to assess the efficacy and safety of BoNT injections for the treatment of certain movement disorders and made recommendations for each therapeutic indication, based upon the strength of clinical evidence. Expand
Botulinum toxin in the treatment of dystonic tics
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TLDR
BTX injections appear to be safe and effective treatment for patients with focal dystonic tics, and ameliorates not only involuntary movements but also the premonitory sensory component associated with some tics. Expand
Botulinum Toxin for the Treatment of Tremor and Tics.
TLDR
Botulinum toxin injections can provide meaningful improvement in patients with localized tremors and tics; in some cases, they may be an alternative to other treatments with more undesirable adverse effects. Expand
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Clinical Practice: Evidence-Based Recommendations for the Treatment of Cervical Dystonia with Botulinum Toxin
TLDR
While the beneficial effect of botulinum toxin treatment on different aspects of CD is well established, robust evidence is still missing concerning some practical aspects, such as dose equivalence between different formulations, optimal treatment intervals, treatment approaches, and the use of supportive techniques including electromyography or ultrasounds. Expand
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TLDR
The major forms of focal and task-specific dystonia are reviewed, along with the evidence for BoNT therapy, the expected benefit and side effects, and practical points guiding the injections. Expand
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TLDR
Objective evaluation failed to demonstrate significant improvement following treatment with toxin compared with placebo, and the major side effect was transient focal weakness after 53% of injections of toxin. Expand
Lingual protrusion dystonia: frequency, etiology and botulinum toxin therapy.
TLDR
It is concluded that LPD is rare, most commonly the result of tardive and primary dystonia, and botulinum toxin therapy may be very effective but needs to be utilized with care because of the possibility for the development of dysphagia. Expand
Safety and efficacy of NeuroBloc (botulinum toxin type B) in type A-responsive cervical dystonia.
TLDR
Improvements associated with BoNT/B treatment were greatest for patients who received the 10,000-U dose, and Botulinum toxin type B (NeuroBloc) is safe and efficacious at 5,000 U and 10, thousand U for the management of patients with cervical dystonia. Expand
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TLDR
Botulinum toxin A exerts a modest tremorlytic effect, however the dose, and its distribution over the sites injected, need to be optimised to minimise focal weakness. Expand
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