• DOI:10.1097/PHM.0b013e31813e2b4d
• Corpus ID: 23883804

Botulinum Toxin A, Evidence-Based Exercise Therapy, and Constraint-Induced Movement Therapy for Upper-Limb Hemiparesis Attributable to Stroke: A Preliminary Study

@article{Levy2007BotulinumTA,
  title={Botulinum Toxin A, Evidence-Based Exercise Therapy, and Constraint-Induced Movement Therapy for Upper-Limb Hemiparesis Attributable to Stroke: A Preliminary Study},
  author={Charles E Levy and Clare G Giuffrida and Lorie G. Richards and Sam Wu and Sandra E Davis and Stephen E. Nadeau},
  journal={American Journal of Physical Medicine \& Rehabilitation},
  year={2007},
  volume={86},
  pages={696-706}
}

• C. Levy, C. Giuffrida, +3 authors S. Nadeau
• Published 1 September 2007
• Psychology, Medicine
• American Journal of Physical Medicine & Rehabilitation

Levy CE, Giuffrida C, Richards L, Wu S, Davis S, Nadeau SE: Botulinum toxin A, evidence-based exercise therapy, and constraint-induced movement therapy for upper-limb hemiparesis attributable to stroke: a preliminary study. Am J Phys Med Rehabil 2007;86:696–706 Objective:To determine whether the combination of botulinum toxin A (BTX-A) treatment for the upper limb and a 4-wk course of exercise therapy could improve motor function sufficiently to allow those with poststroke hemiparesis and spasticity to achieve the minimal motor criteria (MMC) to be enrolled in constraint-induced movement therapy (CIMT), and to determine the feasibility of enrolling participants into CIMT if they meet MMC after treatment with a combination of BTX-A plus exercise therapy. Design:Twelve individuals received BTX-A and exercise therapy for 1 hr/day, three times per week, for 4 wks. Those who met MMC were enrolled in 2 wks of CIMT, and the rest received a home exercise program. Outcome measures included the Ashworth Scale, Wolf Motor Function Test (WMFT), the Motor Activity Log (MAL), the Box and Blocks Test (BBT), and the upper-extremity subtest of the Fugl–Meyer Assessment of Motor Function (FM-UE). Results:Ashworth Scale scores declined from a mean score of 2.0–1.2 (P = 0.01). Four of 12 subjects were able to achieve MMC (P = 0.026). CIMT participants improved in the BBT, the MAL, and the WMFT compared with their own baseline. Gains achieved during CIMT receded by week 24 as spasticity returned. Conclusion:BTX-A plus exercise therapy shows potential to improve function for those with severe hand paresis and spasticity after stroke. Those who meet MMC may initially realize further modest gains through CIMT. However, gains are likely to recede as spasticity returns. Adding medications or modifying the therapy protocol to include activities such as functional neuromuscular stimulation or robotic training may yield a more potent effect.