Botulinum Toxin: Mechanisms of Action

  title={Botulinum Toxin: Mechanisms of Action},
  author={D. Dressler and F. Adib Saberi},
  journal={European Neurology},
  pages={3 - 9}
  • D. Dressler, F. Adib Saberi
  • Published 2005
  • Biology, Medicine
  • European Neurology
  • Botulinum toxin (BT) has been perceived as a lethal threat for many centuries. In the early 1980s, this perception completely changed when BT’s therapeutic potential suddenly became apparent. We wish to give an overview over BT’s mechanisms of action relevant for understanding its therapeutic use. BT’s molecular mode of action includes extracellular binding to glycoprotein structures on cholinergic nerve terminals and intracellular blockade of the acetylcholine secretion. BT affects the spinal… CONTINUE READING
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