Botulinum Toxin: Mechanisms of Action

@article{Dressler2005BotulinumTM,
  title={Botulinum Toxin: Mechanisms of Action},
  author={Dirk Dressler and Fereshte Adib Saberi},
  journal={European Neurology},
  year={2005},
  volume={53},
  pages={3 - 9}
}
Botulinum toxin (BT) has been perceived as a lethal threat for many centuries. In the early 1980s, this perception completely changed when BT’s therapeutic potential suddenly became apparent. We wish to give an overview over BT’s mechanisms of action relevant for understanding its therapeutic use. BT’s molecular mode of action includes extracellular binding to glycoprotein structures on cholinergic nerve terminals and intracellular blockade of the acetylcholine secretion. BT affects the spinal… 
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References

SHOWING 1-10 OF 47 REFERENCES
Botulinum A toxin effects on rat jaw muscle spindles.
TLDR
The Botox effect on muscle spindles suggests that the relief from dystonias could be due not only to a partial motor paralysis, but also to a decrease of the reflex muscular tone.
[Presynaptic effects of botulinum toxin type A on the neuronally evoked response of albino and pigmented rabbit iris sphincter and dilator muscles].
TLDR
Data indicated that botulinum A toxin may inhibit not only the acetylcholine release in the cholinergic nerve terminals, but also substance P release from the trigeminal nerve terminals of the rabbit iris sphincter muscle.
Effects of type a botulinum toxin on the cholinergic transmission at spinal renshaw cells and on the inhibitory action at ia inhibitory interneurones
TLDR
It is suggested that on the spinal level the central action of botulinum toxin predominantly passes on the motoneurones.
Neuromuscular effects distant from the site of botulinum neurotoxin injection
TLDR
The effects observed are compatible with stimulation of terminal sprouting by the neurotoxin, without significant presynaptic inhibition of acetylcholine release, and believe that higher dosages of the neurot toxin may be used if clinically indicated.
Botulinum toxin restores presynaptic inhibition of group Ia afferents in patients with essential tremor
TLDR
Findings show that botulinum toxin treatment restores presynaptic inhibition between forearm antagonist muscles, which probably depend upon the toxin's concurrent action on the extrafusal and intrafusal motor end‐plates, the latter resulting in decreased spindle afferent input to the spinal cord.
Botulinum toxin therapy: distant effects on neuromuscular transmission and autonomic nervous system.
To evaluate distant effects of botulinum toxin, single fibre electromyography on the extensor digitorum communis muscle and six tests of cardiovascular reflexes were performed in five patients
Differential inhibition by botulinum neurotoxin A of cotransmitters released from autonomic vasodilator neurons.
TLDR
The results demonstrate that the SNARE complex has differential involvement in release of cotransmitters from the same autonomic neurons: NO release is not dependent on synaptic vesicle exocytosis, acetylcholine release from small vesicles is highly dependent on theSNARE complex, and neuropeptide release from large vESicles involves SNARE proteins that may interact differently with regulatory factors such as calcium.
Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action.
TLDR
Tetanus toxin and Botulinum neurotoxins implicate a calmodulin-independent locus (or loci) of action common to small- and large-dense-core vesicles and associated with vesicle transport that affects a step common to both exocytotic pathways.
125I-Labelled botulinum a neurotoxin: Pharmacokinetics in cats after intramuscular injection
TLDR
A disto-proximal gradient of radioactivity (RA) had developed in the sciatic nerve of the injected side of the cat and was strictly confined to the intraaxonal space of a few nerve fibres.
Effects of botulinum toxin type A on intracortical inhibition in patients with dystonia
TLDR
The data suggest that botulinum toxin can transiently alter the excitability of the cortical motor areas by reorganizing the inhibitory and excitatory intracortical circuits.
...
1
2
3
4
5
...