Botulinum Toxin: Mechanisms of Action

@article{Dressler2005BotulinumTM,
  title={Botulinum Toxin: Mechanisms of Action},
  author={D. Dressler and F. Adib Saberi},
  journal={European Neurology},
  year={2005},
  volume={53},
  pages={3 - 9}
}
  • D. Dressler, F. Adib Saberi
  • Published 2005
  • Biology, Medicine
  • European Neurology
  • Botulinum toxin (BT) has been perceived as a lethal threat for many centuries. In the early 1980s, this perception completely changed when BT’s therapeutic potential suddenly became apparent. We wish to give an overview over BT’s mechanisms of action relevant for understanding its therapeutic use. BT’s molecular mode of action includes extracellular binding to glycoprotein structures on cholinergic nerve terminals and intracellular blockade of the acetylcholine secretion. BT affects the spinal… CONTINUE READING
    144 Citations
    Neurophysiological changes after intramuscular injection of botulinum toxin
    • 31
    • PDF
    Botulinic Toxin Type A: action mechanism
    • 3
    • PDF
    Expanding use of botulinum toxin
    • 104
    Botulinum Neurotoxin: The Ugly Duckling
    • 21
    Botulinum toxin and its clinical aspects: An overview
    • 3
    • PDF
    Chapter 11 Botulism
    • 76
    Neurophysiological effects of botulinum toxin type a
    • 67

    References

    SHOWING 1-10 OF 48 REFERENCES
    Neuromuscular effects distant from the site of botulinum neurotoxin injection
    • 126
    Botulinum toxin therapy: distant effects on neuromuscular transmission and autonomic nervous system.
    • 161
    • PDF
    Differential inhibition by botulinum neurotoxin A of cotransmitters released from autonomic vasodilator neurons.
    • 121
    • PDF
    125I-Labelled botulinum a neurotoxin: Pharmacokinetics in cats after intramuscular injection
    • 164