Botulinum Neurotoxin Devoid of Receptor Binding Domain Translocates Active Protease

@article{Fischer2008BotulinumND,
  title={Botulinum Neurotoxin Devoid of Receptor Binding Domain Translocates Active Protease},
  author={Audrey Fischer and Darren J. Mushrush and D Borden Lacy and Mauricio Montal},
  journal={PLoS Pathogens},
  year={2008},
  volume={4},
  pages={717 - 766}
}
Clostridium botulinum neurotoxin (BoNT) causes flaccid paralysis by disabling synaptic exocytosis. Intoxication requires the tri-modular protein to undergo conformational changes in response to pH and redox gradients across endosomes, leading to the formation of a protein-conducting channel. The approximately 50 kDa light chain (LC) protease is translocated into the cytosol by the approximately 100 kDa heavy chain (HC), which consists of two modules: the N-terminal translocation domain (TD) and… CONTINUE READING