Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond.

@article{Schiavo1994BotulinumGN,
  title={Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond.},
  author={Giampietro Schiavo and Carl J Malizio and William S. Trimble and Patrizia Polverino de Laureto and Gabriella Milan and Hiromu Sugiyama and Eric Arthur Johnson and Cesare Montecucco},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 32},
  pages={20213-6}
}
Similarly to other serotypes, botulinum neurotoxin serotype G (BoNT/G) contains the zinc binding motif of zinc endopeptidases. Highly purified preparations of BoNT/G show a zinc-dependent protease activity specific for VAMP/synaptobrevin, a membrane protein of synaptic vesicles. The two neuronal VAMP isoforms are cleaved with similar rates at one Ala-Ala peptide bond present in the same region, out of the several such peptide bonds present in their sequences. This site of cleavage is unique… CONTINUE READING
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