Botulinolysin, a thiol-activated hemolysin produced by Clostridium botulinum, inhibits endothelium-dependent relaxation of rat aortic ring.

@article{Sugimoto1997BotulinolysinAT,
  title={Botulinolysin, a thiol-activated hemolysin produced by Clostridium botulinum, inhibits endothelium-dependent relaxation of rat aortic ring.},
  author={Nakaba Sugimoto and A Haque and Yasuhiko Horiguchi and Morihiro Matsuda},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1997},
  volume={35 7},
  pages={
          1011-23
        }
}
  • N. Sugimoto, A. Haque, M. Matsuda
  • Published 1 July 1997
  • Biology, Medicine, Chemistry
  • Toxicon : official journal of the International Society on Toxinology
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It is concluded that E. coli hemolysin can elicit thromboxane-mediated pulmonary hypertension combined with severe vascular leakage in isolated lungs in the absence of circulating inflammatory cells and humoral mediator systems, mimicking the key events in the development of acute respiratory failure in states of septicemia.
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TLDR
The purified hemolysin had a lethal effect in mice and was cytotoxic for some cultured cells: its 50% lethal dose in mice was 310 ng, and the 50% cytot toxic dose for Vero cells was 120 ng/ml.
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