Bottom-up construction of in vitro switchable memories.

  title={Bottom-up construction of in vitro switchable memories.},
  author={Adrien Padirac and Teruo Fujii and Yannick Rondelez},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 47},
Reaction networks displaying bistability provide a chemical mechanism for long-term memory storage in cells, as exemplified by many epigenetic switches. These biological systems are not only bistable but switchable, in the sense that they can be flipped from one state to the other by application of specific molecular stimuli. We have reproduced such functions through the rational assembly of dynamic reaction networks based on basic DNA biochemistry. Rather than rewiring genetic systems as… CONTINUE READING
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An introduction to nonlinear chemical dynamics: Oscillations, Waves, Patterns, and Chaos (Oxford University Press, London)

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