Bottlenecks and the Maintenance of Minor Genotypes during the Life Cycle of Trypanosoma brucei

  title={Bottlenecks and the Maintenance of Minor Genotypes during the Life Cycle of Trypanosoma brucei},
  author={Michael Oberle and Oliver Balmer and Reto Brun and Isabel Roditi},
  booktitle={PLoS pathogens},
African trypanosomes are digenetic parasites that undergo part of their developmental cycle in mammals and part in tsetse flies. We established a novel technique to monitor the population dynamics of Trypanosoma brucei throughout its life cycle while minimising the confounding factors of strain differences or variation in fitness. Clones derived from a single trypanosome were tagged with short synthetic DNA sequences in a non-transcribed region of the genome. Infections were initiated with… CONTINUE READING
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