Botox-induced prostatic involution.

  title={Botox-induced prostatic involution.},
  author={Regula Doggweiler and D h Zermann and Manabu Ishigooka and Richard A. Schmidt},
  journal={The Prostate},
  volume={37 1},
BACKGROUND A simple approach to induced prostatic atrophy was explored. Surgical denervation is known to produce profound atrophy of the rat prostate. Because Botulinum toxin type A (Botox) produces a long-term chemical denervation, the potential to induce atrophy of the rat prostate was explored. METHODS Thirty rat prostates were injected with varying doses of Botox. Single and serial injections were used, and rats were subsequently sacrificed after either 1 or 4 weeks, respectively. The… CONTINUE READING