Both total and phosphorylated tau are increased in Alzheimer's disease.

@article{Sjgren2001BothTA,
  title={Both total and phosphorylated tau are increased in Alzheimer's disease.},
  author={Magnus J.C. Sj{\"o}gren and Pia Davidsson and Mats Tullberg and Lennart Minthon and Anders Wallin and Carsten Wikkelso and A. K. Gran{\'e}rus and Hugo Marcel Johan Vanderstichele and Eugeen Vanmechelen and K Blennow},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2001},
  volume={70 5},
  pages={624-30}
}
BACKGROUND [corrected] Pathological tau protein concentrations in CSF are found in both Alzheimer's disease (AD) and frontotemporal dementia (FTD), but studies on brain tissue have suggested that the tau pathology in AD differs from that in FTD and that the difference may be related to the degree of phosphorylation. As CSF tau protein is increased after stroke, tau may also be implicated in the pathophysiology of vascular dementia, of which subcortical arteriosclerotic encephalopathy (SAE) is a… CONTINUE READING

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