Both thyroid hormone and 9-cis retinoic acid receptors are required to efficiently mediate the effects of thyroid hormone on embryonic development and specific gene regulation in Xenopus laevis.

@article{PuzianowskaKuznicka1997BothTH,
  title={Both thyroid hormone and 9-cis retinoic acid receptors are required to efficiently mediate the effects of thyroid hormone on embryonic development and specific gene regulation in Xenopus laevis.},
  author={Monika Puzianowska-Kuznicka and Sashko Damjanovski and Yanbo Shi},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 8},
  pages={4738-49}
}
Tissue culture transfection and in vitro biochemical studies have suggested that heterodimers of thyroid hormone receptors (TRs) and 9-cis retinoic acid receptors (RXRs) are the likely in vivo complexes that mediate the biological effects of thyroid hormone, 3,5,3'-triiodothyronine (T3). However, direct in vivo evidence for such a hypothesis has been lacking. We have previously reported a close correlation between the coordinated expression of TR and RXR genes and tissue-dependent temporal… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 81 references

Retinoid X receptor-selective ligands produce malformations in Xenopus embryos.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 11 Excerpts
Highly Influenced

The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 4 Excerpts
Highly Influenced

Thyroid hormone-induced gene expression program for amphibian tail resorption.

The Journal of biological chemistry • 1993
View 4 Excerpts
Highly Influenced

Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg.

Proceedings of the National Academy of Sciences of the United States of America • 1992
View 5 Excerpts
Highly Influenced

Hedgehog and beyond

M. Puzianowska-Kuznicka
Cell • 1996

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