Both the p33 and p55 subunits of the Helicobacter pylori VacA toxin are targeted to mammalian mitochondria.

@article{Foo2010BothTP,
  title={Both the p33 and p55 subunits of the Helicobacter pylori VacA toxin are targeted to mammalian mitochondria.},
  author={Jung Hock Foo and Janetta Gladys Culvenor and Richard L Ferrero and Terry Kwok and Trevor Lithgow and Kipros Gabriel},
  journal={Journal of molecular biology},
  year={2010},
  volume={401 5},
  pages={
          792-8
        }
}
Helicobacter pylori infection causes peptic ulcers and gastric cancer. A major toxin secreted by H. pylori is the bipartite vacuolating cytotoxin A, VacA. The toxin is believed to enter host cells as two subunits: the p55 subunit (55 kDa) and the p33 subunit (33 kDa). At the biochemical level, it has been shown that VacA forms through the assembly of large multimeric pores composed of both the p33 subunit and the p55 subunit in biological membranes. One of the major target organelles of VacA is… CONTINUE READING
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pylori infection

  • K. Wooldridge
  • Bacterial Secreted Proteins : Secretory…
  • 2009

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