Both the anti- and pro-apoptotic functions of villin regulate cell turnover and intestinal homeostasis

@inproceedings{Wang2016BothTA,
  title={Both the anti- and pro-apoptotic functions of villin regulate cell turnover and intestinal homeostasis},
  author={Yaohong Wang and Sudeep P. George and Swati Roy and Eric Pham and Amin Esmaeilniakooshkghazi and Seema Khurana},
  booktitle={Scientific reports},
  year={2016}
}
In the small intestine, epithelial cells are derived from stem cells in the crypts, migrate up the villus as they differentiate and are ultimately shed from the villus tips. This process of proliferation and shedding is tightly regulated to maintain the intestinal architecture and tissue homeostasis. Apoptosis regulates both the number of stem cells in the… CONTINUE READING